IGHE and allergic disease: The wide gamut of signs seen in allergic diseases ranging from the mild skin rashes and gastrointestinal symptoms, to more severe signs such as pulmonary distress and systemic anaphylaxis, could be due to different levels of contributions of HRF dimer/oligomers as well as other factors such as variable antigen valencies and concentrations or FcεRI occupancy by antigen-specific IgE.