Upon infection, respiratory epithelial cells sense virus through Toll-Like Receptors (TLRs), retinoic acid-inducible gene I (RIG-I), NOD-like receptors (NLRs), and melanoma differentiation-associated 5 (MDA-5), leading to the expression of type-I and type-III interferons (IFN), interleukin-6 (IL-6), IL-1β, IL-18, and other pro-inflammatory cytokines and chemokines [56,57,58,59]. Here, RIGI is linked to infection.