Another promising target antigen is FMS-like tyrosine kinase 3 (FLT3), which could be successfully exploited using FLT3-targeting CAR-T cells demonstrating potent reactivity against AML blasts expressing wild-type or FLT3 with internal tandem duplication (FLT3-ITD) [82]. Here, FLT3 is linked to acute myeloid leukemia.