CSPG4 and neoplasm: Moreover, the interaction of CSPG4 with the extracellular matrix of the tumor microenvironment turns on FAK signaling, resulting in integrin rearrangement and recruitment of cell division control protein 42 homolog (CDC42), activated CDC42 kinase 1 (ACK-1), and p130cas leading to remodeling of the actin cytoskeleton [26,52].