A recent GWAS analysis performed on large numbers of individuals indicated the heterogeneous polygenetic predisposition to AD in the APOE region, as there are no less than 30 polymorphisms from genes BCAM, NECTIN2, TOMM40, APOE, and APOC1 in region 19q13.3 [174], as well as associations with other pathologies such as infections, cancer, diabetes [175,176], and epigenetic changes of the regulatory elements within the apolipoprotein cluster [177]. The gene discussed is APOE; the disease is Alzheimer disease.