APOC1 and hyperlipoproteinemia type 3: One of the best characterized is the HpaI polymorphism (rs 11568822) (allele H2), generated by the insertion of the CGTT sequence in the position −317 of APOC1 promoter [44], which leads to an increased level of apoC1, with subsequent type III hyperlipoproteinemia [45] and also raises serum C-reactive protein [46].