APOE and early-onset autosomal dominant Alzheimer disease: Extensive research was carried out on apoE, as a result of two major discoveries related to two dreadful pathologies of the modern developed societies: (i) apoE deficient mice (APOE−/−) spontaneously develop atherosclerosis [18] and (ii) APOE4 allele is a genetic risk factor for Alzheimer’s disease [19].