TGFB1 and systemic sclerosis: In patients suffering from systemic sclerosis, the anti-TGFB monoclonal antibody fresolimumab, which targets the 3 TGFB isoforms (TGFB1, TGFB2, and TGFB3), was shown to be well tolerated and clinically efficient in a phase II clinical trial [96].