Moreover, according to the BioGrid database, SOX2 and SMAD1 themselves interact with 3 TFs encoded by genes of the gliosis-associated co-expression module we identified in MS SCs: the androgen receptor (AR), GLIS3 (GLIS family zinc finger 3), and NFIB (nuclear factor I B). The gene discussed is SMAD1; the disease is myeloid sarcoma.