IFNG and infection: Some of the important parameters of immune protection for both routes of infection would include protection against acute infection with some mediation against chronic infection, induction of sterile immunity after acute or chronic infection, an increase in both humoral (IgG, and possibly IgA) response, and cell-mediated (involvement of interferon (IFN)-γ producing T-cells) immune responses that might induce a longer lasting protective response [12].