In another study, Stat3 suggested mixed nuclear and cytoplasmic staining in head and neck squamous cell carcinoma, and the high nuclear Stat3 expression contributed to an increase in progression‐free survival by 42.2 months.24 Conversely, the expression of pStat3 in tumour tissues was found to be related to poor prognoses of head and neck squamous cell carcinoma, renal cell cancer, colorectal cancer and gastric cancer.8, 25, 26, 27 In this study, a significant correlation between the nuclear pStat3 expression and a low prognosis in EOC patients was detected. This evidence concerns the gene STAT3 and colorectal cancer.