NPPA and hydrops fetalis: Finally, we also measured the mRNA expression of ANP and β-MHC, two hypertrophic biomarkers in left ventricle tissues, showing that compared with WKY- ND, the expression of ANP and β-MHC of OBH-HF were significantly up-regulated (P < 0.05) while could be down-regulated after HQQR treatment for 10 weeks (P < 0.01 or P < 0.05) (Figure 2E).