Cathecolamines and Ang II activate RhoA via the membrane G protein‐coupled receptor, and ROCK is an effector of active RhoA.1 Ang II infusion in rats causes cardiac hypertrophy, which is suppressed by fasudil.34 In DOCA hypertensive rats, fasudil reduces blood pressure and angiotensin II and increases Ang‐(1‐9) levels.35 The gene discussed is AGT; the disease is cardiac hypertrophy.