Methylenetetrahydrofolate dehydrogenase 2 was found to be co‐expressed with cell cycle proteins to progress cancer cell proliferation.13, 18 To explore the molecular mechanisms underlying the oncogenic role of MTHFD2, mRNA profiling was employed to obtain potential genes and pathways regulated by MTHFD2 via comparing DEGs between MTHFD silencing and empty virus‐transfected H1299 cells. The gene discussed is MTHFD1; the disease is cancer.