Several reports have shown that PLP2 is highly expressed in extracranial cancers where it has been shown to promote tumour growth and metastasis.4, 22, 23 To assess the biological role of PLP2 in glioma, we knocked down PLP2 expression in U87 and U251 GBM cells, using two small interfering RNAs (siPLP2‐1 and siPLP2‐2). Here, PLP2 is linked to central nervous system cancer.