PLP2 has previously been identified as a protein enriched in the colonic epithelium.31 PLP2 contains four putative membrane‐spanning α‐helices which multimerize to form ion channels.3 In cancer, PLP2 has been reported to have an oncogenic role in melanoma, breast cancer and osteogenic sarcoma.4, 5, 6 In the present study, we found that PLP2 was highly expressed in high‐grade gliomas relative to low‐grade gliomas and normal brain tissues based on data from three publicly available databases and in our own cohort of clinical samples. Here, PLP2 is linked to glioma.