Strikingly, these experiments confirmed that the therapeutic action of recombinant human BiP in patients with active RA was not reliant on the continued presence of the protein and suggested that one mechanism of action of BiP may be to induce differentiation of immunoregulatory T cells to correct the immunological imbalance induced by inflammation and, ultimately, to restore homeostasis 10, 11. The gene discussed is HSPA5; the disease is rheumatoid arthritis.