Elevation of hippocampal Igf-II DMR 2 methylation, upregulation of l-methionine and DNA methyltransferase 1. Intra-hippocampal injection of recombinant Igf-II reactivated repressed calcium calmodulin kinase II α and reversed cognitive deficits in exposed offspring [121]. Here, DNMT1 is linked to Cognitive impairment.