Overexpression of JHDM1D-AS1 promoted the growth of tumor cells both in vivo and in vitro, which was mainly related to the increased expression of some tumor-derived angiogenic factors such as human hepatocyte growth factor (hHGF), human fibroblast growth factor 1 (hFGF1), and several inflammatory response genes, including mouse matrix metalloproteinase3 (mMmp3), mouse matrix metalloproteinase9 (mMmp9), mouse S100A8 protein (mS100a8), and mouse S100A9 protein (mS100a9) 47. Here, S100A8 is linked to neoplasm.