Expressions of five potential DNA methylation-driven genes were performed and it was found that only LAT, HOXD3 and NFE2L3, not LUCAT1 and HHLA2, were significantly up-regulated or downregulated in ccRCC samples compared with normal tissues, as shown in Figure 4A-C (left panel), Figure S1A-B. The gene discussed is HHLA2; the disease is nonpapillary renal cell carcinoma.