The results of the KEGG pathway analysis showed that ubiquitin mediated proteolysis, renal cell carcinoma, ErbB signaling pathway, et al were significantly top-enriched for LAT gene; primary immunodeficiency, cytokine-cytokine receptor interaction, homologous recombination, et al were significantly enriched for HOXD3; antigen processing and presentation, cell adhesion molecules CAMS, et al were significantly enriched for NFE2L3 (Figure 5 left panel, Table S2). This evidence concerns the gene EGFR and hereditary clear cell renal cell carcinoma.