CD274 and cancer: Therefore, we could since speculate that in cases with poor outcomes included those that both raised NLR and broad PD-L1 expression, inflammation-induced PD-L1 expression may be dominant, and an immunosuppressive state in relation to over-production of neutrophils may have occurred, and at the same time, PD-1-mediated tumor immune escape by which the cancer cells can become progressive may have also been activated.