ACLY and cancer: De novo synthesis of FA is activated in cancer cell, which is catalyzed by ATP citrate lyase (ACLY), acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN), then converted to monounsaturated FA (MUFA) to generate triacylglycerol (TAG), the composition of LDs, by stearoyl-CoA desaturase (SCD) (Figure 1).