Specifically, overexpression of FASN (HR=2.10, P<0.001) exhibited a poor OS, and overexpression of ACLY (HR=0.52, P<0.001), CPT1A (HR=0.47, P<0.001), HADHA (HR=0.48, P<0.001), HADHB (HR=0.38, P<0.001), and ACAT1 (HR=0.42, P<0.001) showed a favorable OS in ccRCC patients. The gene discussed is HADHA; the disease is nonpapillary renal cell carcinoma.