In conclusion, we elucidated the mRNA expression dysregulation of multiple FA metabolic enzymes, i.e., ACLY, ACC, FASN, SCD, CPT1A, HADHA, HADHB, and ACAT1, in ccRCC and normal tissues using Oncomine and GEPIA analyses, then evaluated the prognostic significance of these metabolic enzymes in ccRCC patients using Kaplan-Meier plotter and GEPIA analyses. Here, CPT1A is linked to nonpapillary renal cell carcinoma.