In conclusion, we elucidated the mRNA expression dysregulation of multiple FA metabolic enzymes, i.e., ACLY, ACC, FASN, SCD, CPT1A, HADHA, HADHB, and ACAT1, in ccRCC and normal tissues using Oncomine and GEPIA analyses, then evaluated the prognostic significance of these metabolic enzymes in ccRCC patients using Kaplan-Meier plotter and GEPIA analyses. This evidence concerns the gene ACAT1 and nonpapillary renal cell carcinoma.