Meanwhile FA β-oxidation (FAO) remains obscure in cancer cell, which is catalyzed by carnitine palmitoyltransferase 1A (CPT1A), hydroxyl-coenzyme A dehydrogenase alpha subunit (HADHA), hydroxyl-coenzyme A dehydrogenase beta subunit (HADHB), and acetyl-coenzyme A acetyltransferase 1 (ACAT1) 9, 14. This evidence concerns the gene HADHB and cancer.