Results showed that most of them were hazard factors, i.e., overexpression of ACC (HR 95%CI =1.43 (1.03-1.99), P=0.033), FASN (HR 95%CI =2.07 (1.54-2.79), P<0.001), and SCD (HR 95%CI =1.41 (1.03-1.93), P=0.032) exhibited a poor OS in ccRCC patients. Here, SCD is linked to nonpapillary renal cell carcinoma.