Recently, aberrant cytoplasmic localization of PML was observed in NPM1-mutated AML cells 26, and the PML delocalization was mediated by interacting with NPM1 mutant 27, which suggests that NPM1 mutant might be implicated in the regulation of EMT-related genes expression via cPML in AML. This evidence concerns the gene NPM1 and acute myeloid leukemia.