In this study, we focused on the up-regulated genes: VCAN and DSC2. Next, we downloaded the RNA-seq data of VCAN and DSC2 genes in a panel of leukemia-lymphoma cell lines from the website of the Cancer Cell Line Encyclopedia (CCLE, https://portals.broadinstitute.org/ccle/home), and detected higher VCAN expression in NPM1-mA positive OCI-AML3 cells (Figure 1D). The gene discussed is VCAN; the disease is leukemia.