NF-κB target genes are associated with numerous hallmarks of cancer, including proliferation (e.g., MYC, Cyclin D1), survival (e.g., BCL-2, Bcl-XL) inflammation (e.g., COX2, TNF-α) and metastasis (e.g., TWIST1, MMP2) 17. This evidence concerns the gene NFKB1 and cancer.