Since EGCG could inhibit lung cancer cell proliferation via downregulation of NF-κB as shown by MTT assays, CI index analyses and colony formation assays were performed to measure the proliferation of A549 and H1299 cells after treatment with EGCG and different concentrations of BAY11-7082 (a specific NF-κB inhibitor) to determine whether EGCG combined with BAY11-7082 has an synergistic effect. This evidence concerns the gene NFKB1 and lung cancer.