Interleukin-6 (IL-6) is produced and secreted by various cell types, including tumor cells, is a pro-inflammatory molecule, whose overexpression has been reported in serum and tumor samples from patients with various types of cancer, including prostate cancer 7, multiple myeloma 8, renal cell carcinoma 9, and breast cancer 10. Here, IL6 is linked to hereditary clear cell renal cell carcinoma.