In cervical carcinoma, IL-6 induces EMT via STAT3 39, while in lung cancer, IL-6 not only promotes the self-renewal of CD133+ CSC-like cells, but also upregulates the expression of EMT-related genes (N-Cadherin, Vimentin, and TWIST), and reduces levels of E-cadherin 40. The gene discussed is PROM1; the disease is lung cancer.