Protein chip arrays and western blot validated that the up-regulated genes after transfecting with pcDNA-PCAT-1 in MM cells were involved in MAPK signaling pathway, in which the ERK1/2, JNK and p38 pathways are involved to regulate cell physiology and are also reported to be activated in MM 28-30. This evidence concerns the gene MAPK8 and Miyoshi myopathy.