IGF2 and Hypoglycemia: Altogether, in the serums of patients suffering from NICTH increased levels of free IGF-II were found, and also of “big” IGF-II with greater capillary permeability, and thus increased IGF bioavailability to the tissues; these combinations can lead to hypoglycemia as a result of increased glucose utilization in the skeletal muscles and also suppressed gluconeogenesis and glycogenolysis in the liver 10, 11.