A large scale cross sectional study PROMIS (Pakistan Risk Of Myocardial Infarction Study) involving 9015 Pakistani patients with acute MI and 8629 matched controls analyzed various biochemical and genetic variants with coronary artery disease, reported that OR of ischemic heart disease increases by 1.10 per 1 SD increase in Lp(a) concentration, even after adjusting for Lp(a) isoform and conventional lipids concentration.14 The gene discussed is LPA; the disease is myocardial infarction.