These approaches biologic agents of B cell therapies include: block BLyS, modulate B cell signaling, neutralise soluble BLyS, induce depletion of B cells, block with all three forms of BLyS.20-24 The causes of the results are unclear, while biologic agents in treatment of systemic lupus erythematosus are still a long way to go whatever in safe or efficacy. Here, TNFSF13B is linked to systemic lupus erythematosus.