This meta-analysis has revealed that elevated levels of CRP in healthy subjects are significantly associated with high-risk in Type-II DM.13 It has also been shown that CRP values could be used to predict DM complications in a recent study assessing the relationship between inflammatory markers and endothelial dysfunction in patients with DM.14 The authors also reported that well-controlled metabolic features in DM might reduce the CRP levels.14 Roy et al.15 said that increased CRP levels were independent predictors of the incidence of cardiovascular disease in patients with DM. This evidence concerns the gene CRP and cardiovascular disorder.