ANXA1 and central nervous system cancer: 4ANXA1 regulates physiological mechanisms such as hormone secretion, apoptosis, exocytosis and signal transduction. miR-196a acts by targeting ANXA1 and suppressing it, thereby promoting cell proliferation and suppressing apoptosis and this provides evidence for its oncogenic potential.5 Expression levels of ANXA1 detected in different cancers are not consistent. In certain tumors such as head and neck, esophageal squamous cell and prostate cancers they are down regulated and in others like glioma and oropharngeal cancers they are up regulated.6