Interestingly, an SNP in ALDH1L1 was reported to be associated with ischemic stroke in the Framingham Heart Study.(9) Secondly, Parvimonas, a Gram-positive anaerobic coccus, was also of interest according to recent knowledge on the association between periodontal disease and ischemic stroke.(10) Fak et al.(11) reported that bacteria from the oral cavity and gut can be recovered from atherosclerotic plaque, and that the abundance of oral Parvimonas was positively associated with c-reactive protein (CRP) in atherosclerotic patients. This evidence concerns the gene ALDH1L1 and periodontal disorder.