In previous large cohort studies, the intake of non-nutritive sweeteners decreased body weight and the risk of type 2 diabetes and coronary heart diseases.(15) However, recent studies have demonstrated that non-nutritive sweeteners stimulate adipogenesis and suppress lipolysis,(16) but they do not influence the secretion of satiety hormones glucagon-like peptide-1 (GLP-1) and peptide YY or ghrelin from the intestines, gastrointestinal satiety peptides.(17) Thus, the effects of sucrose and non-nutritive sweeteners on energy and glucose metabolism remain uncertain. This evidence concerns the gene GCG and coronary artery disorder.