Obesity is a major problem for menopausal women, but Asians are not as obese as Americans and Europeans.(2) Asians easily develop hyperglycemia when insulin resistance increases due to obesity, since Asians have lower insulin secretion capacity than Caucasians.(3) Consequently, Asians with the same body mass index (BMI) have a higher prevalence of metabolic diseases, especially type 2 diabetes, as Americans and Europeans.(2,4) Because Asians have lower thresholds of BMI and body fat mass for obesity related pathologies, obesity is defined at a lower BMI in many Asian countries. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.