Consistent with our results, it has been reported that an AsA treatment improves spatial memory in APP/PSEN1 mice, a mouse model for Alzheimer’s disease, but does not alter monoamine levels in the nucleus accumbens.(42) In the meantime, AsA appears to play a protective role against the excessive action of glutamate receptor in dopaminergic neurons,(4) which suggests that the modulation of cellular signaling may be involved in spatial memory formation. The gene discussed is APP; the disease is Alzheimer disease.