(19) It has been reported that 5% tomato powder decreases the development of aberrant crypt foci (ACF) and adenocarcinoma, along with regulating NRF2/HO-1 signaling pathway in the colorectal tissue of azoxymethane (AOM)-treated Wistar rats.(19) Our previous reports also demonstrated that citrus peel extract significantly activated NRF2, in a human colon cancer cell line, and prevented AOM-induced ACF formation in the colon of F344 rats via antioxidant action.(20). This evidence concerns the gene HMOX1 and malignant colon neoplasm.