Accumulated data suggest that natural compounds can increase Chk2 phosphorylation, resulting in DNA damage–induced apoptosis or G2 phase arrest, apparently through inhibition of topoisomerase II activity.(15,16) Several natural compounds were associated with cell cycle arrest via the activated ATM/Chk2 signaling pathway in the presence or absence of p53 activation.(17,18) Therefore, it is worthwhile to investigate the correlation between NC and Chk2 in cervical cancer. The gene discussed is CHEK2; the disease is cervical cancer.