Increased expression of IL‐22BP by T‐cells in inflammatory bowel disease (IBD) patients promotes cancer development.156, 157 Intestinal inflammation in IBD patients regularly triggers the development of cancer,158, 159 further confirming that inflammation is an additional hallmark of cancer.160 However, the protective role of IL‐22 in intestinal homeostasis can be extended to colon cancer. The gene discussed is IL22RA2; the disease is inflammatory bowel disease.