HIV and SIV infection break down the intestinal barrier leading to disruption of the intestinal integrity and transition of intestinal antigens followed by systemic inflammation.135 Patients with HIV infections have been reported with perturbations of the bacterial microbiota together with expansion of the virome.136 Upon HIV/SIV infection, intestinal CD4 T‐cells as well as ILC populations, specifically ILC3s, are massively decreased.137 HIV is not able to directly infect ILCs as they lack both co‐receptors used by HIV for viral docking, namely CCR5 and CD4. The gene discussed is CD4; the disease is HIV infectious disease.