This dysregulation triggered the formation of colon cancer upon AOM treatment, highlighting the importance of IL‐22 in colon cancer carcinogenesis.46 In the same study, they could also demonstrate that dietary‐derived AhR ligands directly induce genotoxic stress in intestinal epithelial cells, while at the same time promoting IL‐22 production in ILC3s, which in return switches on the DNA damage response in intestinal epithelial cells. Here, AHR is linked to colonic neoplasm.