IL22 and infection: All three groups of IFNs are important in the defense against Rotavirus, but type III IFNs (IFN‐λ) are only acting on and triggering intestinal epithelial cell immunity.145 Moreover, synergy between IL‐22 produced by ILC3s and IFN‐γ has been identified,146 further highlighting the strong interaction of ILCs and epithelial cells during infection.