DHA could alleviate H/R injury in HBVPs by increasing Ang-1 expression and the Ang-1/Ang-2 ratio and decreasing VEGF expression, which may be related to an increase in SSeCKS activation, and may be a new therapeutic target to mitigate cerebral ischemia/reperfusion injury. The gene discussed is ANGPT1; the disease is Cerebral ischemia.