Further studies showed that downregulated Ang-1 expression is closely related to blood–brain barrier function after cerebral ischemia and that the administration of Ang-1 can alleviate injury to the blood–brain barrier induced by ischemia, while Ang-2 and VEGF cause damage blood–brain barrier permeability [34, 35]. The gene discussed is ANGPT1; the disease is Cerebral ischemia.