In mice, loss of Gpd2 is associated with decreased insulin secretion (Eto et al. 1999); loss of Neurod1 is associated with hyperglycemia (Naya et al. 1997); loss of Mapk8ip1 is associated with abnormal gluconeogenesis and increased insulin sensitivity (Morel et al. 2010). This evidence concerns the gene INS and Hyperglycemia.