Upregulation of circ-DONSON, circAKT3, and circDLST [8, 11, 13] or downregulation of KIAA1244, circPSMC3, and circFAT1(e2) [14-16] is regarded as independent prognostic factors of poor prognosis in patients with GC. The gene discussed is DONSON; the disease is gastric cancer.