Induction of apoptosis in GIST-T1 and GIST882 cells after combination of imatinib and CX4945 treatment was greater than after KIT suppression alone, with nuclear fragmentation observed in 35.3 and 48.1% of cells treated with imatinib and CX4945 (Fig. 3e). This evidence concerns the gene KIT and gastrointestinal stromal tumor.