To test the efficacy of new co-potentiators in human airway cell models, short-circuit current was measured in 16HBE14o- human airway epithelial cells in which the endogenous CFTR gene was edited to contain the N1303K mutation (16HBE-N1303Kge21) and in primary cultures of human bronchial epithelial cells from a N1303K homozygous CF subject. This evidence concerns the gene CFTR and cystic fibrosis.