Sema4C, the target of many miRNAs including miR-125b, miR-25-3p, miR-205, miR-138, and miR-31, is involved in the EMT-mediated chemotherapeutic resistance of many malignant tumors, including breast cancer, cervical cancer, HCC, and lung cancer17–20. This evidence concerns the gene SEMA4C and breast cancer.