SEMA4C and cancer: Increasing studies have indicated that Sema4C plays important regulatory roles in tumor invasion, metastasis and EMT and that Sema4C the target of a number of microRNAs (miRNAs) including miR-125b, miR-138, miR-31, miR-25-3p, and miR-205 is involved in EMT-mediated chemotherapeutic resistance of many malignant tumors, including breast cancer, lung cancer, cervical cancer, and HCC17–20.