Intracellular debris presenting as potential zebra bodies, indicative of a lysosomal associated disorder13, were mainly seen in podocytes after the knockdown of any of the HPS proteins (Fig. 5B) Interestingly, the presence of this intracellular debris in podocytes was not limited to zebrafish larvae with phenotype changes associated with proteinuric kidney disease such as edema and pericardial effusion, which suggests that podocytes are associated with the renal phenotype in HPS to a varying degree between the HPS subtypes. The gene discussed is HPS1; the disease is Hermansky-Pudlak syndrome.