In the multivariable analysis, time-averaged overhydration status was a powerful independent predictor of LV systolic dysfunction (OR 4.020, 95% CI [1.285–12.573], p = 0.017) after adjusting for age, sex, presence of DM, cause of ESRD, PD duration, baseline OH, time-averaged D/P creatinine from 4-hr PET, time-averaged pulse pressure, time-averaged haemoglobin, time-averaged glucose, time-averaged albumin, LA diameter, LV mass index and E/e′ ratio at 12 months. This evidence concerns the gene ALB and diabetes mellitus.