Precedence exists for this type of approach in a MoDC context, with the so-called “SmartDC” platform that utilizes a tricistronic lentiviral vector (LV) encoding for GM-CSF, IL-4, and a melanoma TAA—tyrosine-related protein 2 (TRP2)—to program patient-derived CD14+ monocytes to self-differentiate into TRP2-presenting MoDCs53. The gene discussed is DCT; the disease is melanoma.