WDFY4 and fibrosarcoma: The BEACH domain-containing protein WDFY4 was identified by clustered regularly interspaced short palindromic repeats (CRISPR) screen to be necessary for cross-presentation in both primary splenic cDC1s and ex vivo-differentiated cDC1s, and Wdfy4–/– mice failed to mediate rejection of a highly immunogenic fibrosarcoma model.