Ablation of IL-17 signaling resulted in profoundly (more than 10-fold) increased levels of IL-10 and TGF-β1 mRNAs (Fig. 1b), and significantly induced the expression of Foxp3 in the tumor (Fig. 1b), suggesting a major role of IL-17 signaling in the suppression of anti-inflammatory cytokine production during early stage CRC. This evidence concerns the gene IL10 and colorectal carcinoma.