Prior large-scale efforts have assessed the efficacy of OC screening, using different modalities such as serum CA-125 levels and transvaginal ultrasound imaging, including the Prostate, Lung, Colorectal, and Ovarian Cancer (PULCO) [3] and UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) [7] trials. The gene discussed is MUC16; the disease is ovarian carcinoma.