We elucidated that KHSRP could interact with HNRNPC and HNRNPC-mediated tumor growth and metastasis could be, at least partly, attributed to the activation of IFN-α-JAK-p-STAT1 signaling pathway, which is critical for tumorigenesis and metastasis in NSCLC. Here, KHSRP is linked to non-small cell lung carcinoma.