CDKN2B-AS1 rs2151280 was significantly associated with the risk of NSCLC (CC vs TT: OR = 0.572, 95%CI = 0.334–0.980, P = 0.042; CCvsTC+TT: OR = 0.587, 95%CI = 0.356–0.968, P = 0.037, respectively). Here, CDKN2B is linked to non-small cell lung carcinoma.