CD4 and melanoma: RNA analyses and flow cytometry of PBMCs found the extent of expression of inflammatory transcripts in the tumor and the percentages of circulating central memory (CM) and effector CD4+ and CD8+ T cells correlated in a study of patients with melanoma (n = 43) and non-squamous NSCLC (n = 40), expressed as independent CD4+ and CD8+ CM/effector T-cell ratios [22].