RARRES2 and obesity due to melanocortin 4 receptor deficiency: Other genes with a nearby AD-associated blood DMR at follow-up include KHDRBS2, previously identified in a genome-wide association interaction analysis in relation to AD [39], RARRES2, encoding an adipokine that has been linked to inflammation, obesity, diabetes, and cardiovascular diseases [40], and GNG7, for which Braak stage-associated differential methylation has been reported in cortical glial cells of AD patients [41].