Strikingly, our methylomic profiling in MTG and whole blood both led to the identification of a common DMR associated with AD, close to the transcription start site of OXT. Our design allowed for the disentanglement of specific 5mC and 5hmC signals in the MTG, which, in the case of OXT, suggests they change in opposite directions in relation to AD. This evidence concerns the gene OXT and Alzheimer disease.