CUL3 and Hypertension: Bioinformatics studies shown that miR-192-5p could regulate genes related to both small GTPase mediated signal transduction (CUL3, ARHGAP1, ARHGAP36, ARHGEF39) and sodium transport (ATP1A2, SCL5A12), which have been previously related to the mineralocorticoid receptor [28–31] and sodium/potassium exchange [26, 32, 33] pathways (Table 4), suggesting a role in the etiopathogenesis of arterial hypertension.