We estimate that, in the US alone, the previously discussed RAC1:P29S mutation might be present in 628 new patients carrying the HLA-A*02:01 allele each year (in 556 melanoma patients and in 72 lung small cell, head & neck or uterine carcinomas patients, see Additional file 6 for details). This evidence concerns the gene HLA-A and uterine carcinoma.