CTNNB1:S33C is recurrent in studies LIHC (liver hepatocellular carcinoma) and UCEC (uterine corpus endometrial carcinoma), is predicted to lead to strong binding neo-epitopes for HLA-A*02:01, and has been shown to increase the expression of the Wnt-signalling pathway in hepatocellular carcinoma [31], leading to modulation of the immune response [32] and ultimately to tumor immune escape [33]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.