KIT gene mutations have earlier been reported in gastrointestinal stromal tumors, chronic myeloid leukemia, etc .[48],but has never been reported in OSCC; however, it was found in one of our patients at exon 10, codon 541 c.1621A>C (Met541Leu) as transversion mutation. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.